Exploring cellular biochemistry with nanobodies

Exploring biochemistry and cellular biology with protein libraries.

Polypeptide libraries cast a broad net for defining enzyme and binding protein specificities. In addition to uncovering rules for molecular recognition, the binding preferences and functional group tolerances from such libraries can reveal mechanisms underlying biochemical and cellular processes. Ligands obtained from protein libraries can also provide pharmaceutical lead compounds and even rea...

Exploring and Exploiting Quantum-Dot Cellular Automata

The Full Adders (FAs) constitute the essential elements of digital systems, in a sense that they affect the circuit parameters of such systems. With respect to the MOSFET restrictions, its replacement by new devices and technologies is inevitable. QCA is one of the accomplishments in nanotechnology nominated as the candidate for MOSFET replacement. In this article 4 new layouts are presente...

Grand challenges in cellular biochemistry: the “next-gen” biochemistry

It is said that Biochemistry is a young scientific discipline, making its “formal” debut toward the end of the 1900th century (Manchester, 2000), with seminal works by Buchner (1897, Jaenicke, 2007), (Pasteur and Berthelot, 1906), Hill (1898), Embden and Glaessner (1901), Meyerhof (1911), Parnas (1911), Harden (1911), and, of course, Michaelis and Menten (Johnson, 2013; Michaelis and Menten, 20...

Chemometric and Bioinformatic Analyses of Cellular Biochemistry

Genes as Determiners of Cellular Biochemistry.

Science, a weekly journal, is published each Friday by the American Association for the Advancement of Science at The Business Press, Incorporated, N. Queen St. and McGovern Ave., Lancaster, Pa. Founded in 1880, it has been since 1900 the official publication of the AAAS. Editorial and Advertising Offices, 1515 Massachusetts Avenue, N.W., Washington 5, D. C. Telephone, EXecutive 6060 or 6061. C...